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Though the mechanism remains unclear, these data suggest a relationship between peripheral apoE expression and inflammatory signaling that is isoform-dependent

Improved insulin sensitivity can lead to better glucose regulation and reduce the risk of complications associated with these conditions

In contrast to this result, another recent study by Kovarik et al

A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion

doi: 10.1016/S0300-2977(00)00030-9 51 PlioplysAPlioplysS

First, identifying and targeting patients with an active inflammatory-fibrotic phenotype, typically characterized by elevated baseline IL-6 or high-sensitivity C-reactive protein, or by MRI-PDFF-evidenced steatosis with elevated T1 mapping values