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This leads to pain and ECM breakdown

A SALT score of 7.5% is barely noticeable

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Consistent with this notion, our supplementary experiment using a stronger SDS paradigm (5-minute defeat episodes) revealed a stress-intensity-dependent exacerbation of anxiety-like behaviors: WT mice, which showed no anxiety phenotype under the milder SDS condition, developed clear anxiety-like responses when the stress load was increased, whereas KI mice displayed even more pronounced behavioral impairments

To specifically examine autoprocessing at the proximal site, we engineered the M1-PR precursor

Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice