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TMAO: trimethylamine- N -oxide TMAO is primarily generated from TMA, and meals high in choline, LC, and betaine are key dietary sources of its production

Discussion We chose to perform a placebo-controlled study of VPA in non-ambulatory children with SMA based on encouraging preliminary observations of improved motor function during an open label study [27]

The TMA/FMO3/TMAO pathway driven by gut microbiota is also an important regulator of lipid metabolism (Bennett et al., 2013