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Drug Metabolism and pharmacokinetics of antisense oligonucleotide therapeutics: typical profiles, evaluation approaches, and points to consider compared with small molecule drugs
Though this ancient gene family has been exhaustively studied in different organisms, still the information available about its sequences and gene organization understates its functional diversity
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The median and maximum lifespans observed of control and treated populations for these eight replicates are shown in Supplementary file 4

doi:10.1126/science.330.6012.1732
However, results may vary depending on individual skin conditions and lifestyle factors