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Cellular redox balance and oxidative-stress mechanism work
These events collectively result in mitochondrial dysfunction, elevated ROS, and impaired protein clearance, the triad that drives S misfolding and aggregation
Thus, circadian genes and genes related to tissue deterioration can also form positive feedback loops to maintain tissue homeostasis
doi: 10.1093/eurheartj/ehab777 148 Gonzlez-BlzquezRSomozaBGil-OrtegaMMartn RamosMRamiro-CortijoDVega-MartnEet al
Association of polymorphisms in the estrogen receptor gene with body fat distribution
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