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Biological assays and Western blotting exposed significant gender-specific differences in livers from ibuprofen treated males and females relative to their respective controls

Cells were washed and stored in PBS until imaged

The GCH1BH4 system The GCH1BH4 pathway has been identified as an alternative ferroptosis defense mechanism independent of GPX4 and CoQH [26, 27]

Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects

Fabarius et al., 2021)
