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In PD, early GSH depletion in the substantia nigra precedes dopaminergic neuron loss, suggesting that redox dysfunction may be an inciting event that leads to eventual neuronal damage (Smeyne and Smeyne, 2013)
Under classical VitD deficiency, serum 25(OH)D levels are below 30ng/mL (75nmol/L)
Activation of steroid and xenobiotic receptor (SXR, NR1I2) and its orthologs in laboratory, toxicologic, and genome model species
LDHA and LDHB overexpression promoted the Warburg effect in malignantly transformed GES-1 cells induced by N-nitroso compounds
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The role of NKCC1 in regulation of astroglial ionic fluxes in vivo remains, however, questionable (942)
