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Injectable D3 is absorbed more efficiently than oral supplements

Because your body does not readily store excess amounts, toxicity from B12 is very unlikely, even at the higher doses used in injections

Hypoglycemia the risk rises meaningfully when combined with insulin or sulfonylureas

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Even if you eat healthily and exercise, you may invariably be short on specific nutrients due to poor food quality (soil and pesticides affect nutrient value), stress, or absorption issues

In addition, it protects against chronic hypoxia/reoxygenation-induced retinal injury through various signaling mechanisms 163
