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This failure is largely due to testing exclusively on cancer cell lines grown in liquid medium, a condition that predicts in vivo efficacy to anticancer drugs worse than cell culture in 3D gels [4, 5] and is far from adequately reflecting the therapeutic responsiveness of cancers within their native microenvironment [2, 3]

D.et al (2007)

Our data indicate that Dmrta2 interacts with the NuRD complex and with the multizinc finger Zfp423 and related Zfp521 proteins that are expressed in cortical progenitors (Kamiya et al., 2011

Fatigue is a common symptom in both ME/CFS and Fibromyalgia, with post-exertional malaise (PEM) being a hallmark of ME/CFS

For instance, as noted, they might respond better to steroids or therapies targeting lymphocyte trafficking, whereas Type 1 dominant patients (more TNF, IL-12/23, neutrophils, but few eosinophils) might preferentially respond to other biologics

Osborne, G