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One of the most common cells in the TME is tumor-associated macrophages (TAMs)

Furthermore, matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) produced by retinal pigment epithelium (RPE) cells are critically involved in maintaining the homeostasis of matrix components in the eye tissues [61]

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Plastidial Fe-S clusters are assembled by the sulfur mobilization (SUF) pathway, which contains cysteine desulfurase (EC 2.8.1.7), sulfur transferase (EC 2.8.1.3), Fe-S scaffold complex, and Fe-S carrier proteins

Cytokines By stimulating CAR-T cells with cytokines or introducing cytokine genes to facilitate the expression of these factors, this innovative approach will pave the way for the advancement of fourth-generation CAR-T cell therapy [76]