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USA 112 , E4055E4064 (2015)

doi: 10.1038/nrendo.2014.171 15

Early Treatment Diabetic Retinopathy Study report number 1

It appears to be a powerful tissue defender and an anti-inflammatory drug that regulates the oxidative damage that happens following tissue injury

Khan A, Shafiq` I, Hassan Shah M (2017) Prevalence of Vitamin B12 Deficiency in Patients with Type II Diabetes Mellitus on Metformin: A Study from Khyber Pakhtunkhwa

By means of processes like stimulating Treg cell proliferation and encouraging the transformation of M0-type macrophages into M2-type, IDO creates an immunosuppressive milieu in the TME that facilitates tumor evasion of immune surveillance ( IDO1 plays a key role in immune escape in AML, but targeted therapy is still in the early stage of exploration