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Although both studies utilized GULO -/- C57BL/6 mice, the pathological outcomes differed significantly due to variations in experimental conditions

ruthenicum alleviated the fatigue by regulating the inflammatory responses in mice

The International Journal of Neuroscience, 121

In vivo imaging studies demonstrated increased microglia activation and inflammatory activity in spinal cord during symptomatic stages in the SOD1 G93A mouse model (Dibaj et al., 2011)
