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Funding This work was supported by the National Science and Technology Major Project (2022ZD0117700), the National Natural Science Foundation of China (32270759) and the Research Foundation for Postdoctoral (AUGA5710026124)

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Within the liver vitamins D 2 and D 3 undergo the first of two activating hydroxylation reactions

However, investigation of the effect of UA on such models is limited by the profound differences between humans and e.g., rodents in UA metabolism, primarily due to the loss in humans of a functional uricase