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Toriumi, K., Miyashita, M., Suzuki, K., Yamasaki, N., Yasumura, M., Horiuchi, Y., Yoshikawa, A., Asakura, M., Usui, N., Itokawa, M., & Arai, M

What's happening in the gut

The physiology of vitamin B-12 is a multistep process that is characterized by multiple trafficking events, associations and dissociations among several binding/carrier proteins, specific and multiligand receptor-mediated endocytosis, intracellular trafficking into different cellular compartments, and protein-specific controlled exit (1, 2)

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van der Valk R, Webers CA, Schouten JS, Zeegers MP, Hendrikse F, Prins MH (2005) Intraocular pressurelowering effects of all commonly used glaucoma drugs: a meta-analysis of randomized clinical trials

Handling best practices Minimize the time reconstituted vials spend out of refrigeration Never touch the rubber stopper with anything except an alcohol-swabbed needle Draw doses quickly and return vial to refrigerator immediately Use a fresh needle for each vial entry to minimize contamination risk Never share vials between users Contamination is a significant risk with multi-dose vials