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In juvenile yellow catfish, Wang et al (2021a) documented that acute ammonia exposure (96h) resulted in increased ammonia accumulation in both the intestine and muscle, concomitantly with an altered amino acid composition and enzymatic activity in the muscle

A phase 2/3 multicenter randomized trial of ALCAR versus placebo is expected to begin enrollment in 2025 (NCT06126315)

PMID: 100 FloreanCSongSDicatoMDiederichM

TriMix may be one part of that conversation, but it is not the only option

doi: 10.1096/fasebj.28.1_supplement.844.11

Also, for theophylline with a t 1/2 equal to 4 h, the time to reach 94% of steady-state will be 16 hr