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[DOI] [PMC free article] [PubMed] [Google Scholar] 92.Ritchie K., Chan D., Watermeyer T

Next, the N domain follows: attacking and hydrolyzing the PC and SM within the membrane

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DAMPs such as HMGB1 and S100A8/A9 secreted by adipocytes bind to RAGE, promoting macrophage polarization toward the M1 phenotype and releasing proinflammatory cytokines, thereby exacerbating systemic low-grade inflammation 56,163