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Comparison of sublingual and intramuscular administration of vitamin B12 for the treatment of vitamin B12 deficiency in children

Research has shown that AOD-9604 increases lipolytic activity and reduces body weight gain beyond control groups, indicating effects beyond standard caloric management

Effect sizes were Hedges g values (calculated using rank-transformed data), with non-central 95% Cis, from the 9 patients who performed the phase II

The primary mechanism involves intrinsic factor binding in the stomach, while a secondary pathway allows small amounts to absorb through passive diffusion

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Diet, exercise, and overall lifestyle remain the most important factors for weight management