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Quality of life was assessed by parent reported questionnaires, including the Pediatric Quality of Life (PedsQL) Generic 4.0 and Neuromuscular (3.0) modules, and The Child Behavior Checklist for ages 618 or CBCL/618 (ASEBA 2020)

Increased plasma xanthine and hypoxanthine can also occur consequent to disorders of mitochondrial oxidative phosphorylation or of glycogen metabolism (77)

This difference is influenced by the use of specific experimental inducers

The pathophysiology of ALN involves underlying mechanisms that include direct or indirect effects of alcohol metabolites, impaired axonal transport, suppressed excitatory nerve pathway activity, or imbalance in neurotransmitters [52,53,54]

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For pregnant and breastfeeding women, there is not enough research to confirm its safety, so experts recommend consulting a doctor before use (Saha et al., 2024)