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[Google Scholar] 128.Xiong R.G., et al

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If symptoms persist, a second dose may be administered in the same nostril after 5 minutes

However, natural small molecules, acting as chemical probes, offer a functionally guided approach to biomarker discovery

Because IB normally binds to NF-B, the latter's nuclear localization sequence (NLS) is masked, resulting in its main location in the cytoplasm, while removal of IB exposes the masked site to induce the nuclear translocation of NF-B, making it bind to the promoter regions of its downstream genes [34], such as cyclooxygenase-2 (COX-2), IL-6, and inducible nitric oxide synthase (iNOS)

among these, the expression of TLR-2 is increased in inflammatory skin disorders such as acne and rosacea [91,92]