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Heidorn, S

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The pathogenesis is not fully understood yet

This means that initially, the drug concentration in the blood decreases rapidly, but then it takes a longer time to eliminate the remaining amount from the body
NCOA4 depends on iron levels and is degraded by the proteasome in iron-depleted cells (Mancias et al., 2014[286])

These may include antidepressants, anti-anxiety medications, and medications specifically for managing drug cravings
