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The glutamate produced can either return to the cytoplasm via SLC25A18 and SLC25A22 transporters for the biosynthesis of GSH and non-essential amino acids (e.g., aspartate, alanine, arginine) or undergo complete oxidation or conversion into -KG by mitochondrial transaminases (e.g., GPT2, GOT2) (97, 98)

An orally active catalytic metalloporphyrin protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in vivo

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For maintenance therapy, the frequency may be reduced to once every month, but this depends on individual patient needs and response to treatment

F., & Levine, B