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However, it is important to note that much of the data surrounding BPC-157 is still in the early stages, with much more to explore regarding its underlying mechanisms and practical uses

The Goldstein group at George Washington University has consistently published on TB-500s wound healing mechanisms, with a 2012 paper in the Annals of the New York Academy of Sciences documenting a 70% increase in fibroblast migration rates

W.et al (2014)

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However, small modifications to both the amino group and the methoxy group at position 5 of the benzothiazole core did not result in any significant increase or decrease in binding activity as measured by the CPMG assay, and no reliable LO-NMR K D data could be obtained for the analogues (Supplementary Table 1)