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Microbiota-derived tryptophan metabolism: Impacts on health, aging, and disease

Atrogin-1 and MuRF1 expression in skeletal muscle is increased by cytokines or reactive oxygen species (ROS) and constitutive activation of NF-kB in animal models, leading to muscle loss and atrophy (Ringseis et al., 2013)

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Horstman AM, Dillon EL, Urban RJ, Sheffield-Moore M

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