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Hyperglycemia triggers ROS production through multiple pathways, including the polyol pathway, protein kinase C (PKC) activation, and advanced glycation end product (AGE) formation

Reactive oxygen and nitrogen species (Ros/rns) scavenging assays, oxidative stress biomarkers, and chromatographic/chemometric assays

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I have some modest progress to report

Furthermore, increased MDA levels, a well-known secondary product of lipid peroxidation [423], in the blood and aqueous humor [424], and reduced antioxidant levels [424,425] have been detected in glaucoma patients

[DOI] [PubMed] [Google Scholar] 37.Lojo N., Rasic Z., Sever A.Z., Kolenc D., Vukusic D., Drmic D., Zoricic I., Sever M., Seiwerth S., Sikiric P