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These genes have all been linked to negative regulation of arachidonic acid metabolisma well-established inflammatory pathwayand are also known downstream targets of the redox sensitive Nrf2 transcription factor pathway

Our results provide new insights into the structure of -GCS-GS and suggest -GCS-GS evolved from a monomeric -GCS that became C-terminally fused to a multimeric ATP-grasp protein.

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