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The efficacy and safety of cabozantinib have been tested in a Phase II study (NCT03542877) in heavily pretreated patients with refractory mCRC

Therapeutic implications: modulating nodes, not just scavenging Therapy should target network nodes and compartments, not just mop up oxidants: indiscriminate antioxidant loading can blunt adaptive signalling and leave the upstream drivers untouched, whereas node-specific, compartment-aware strategies act where the chemistry originates and where signals are decoded

Nrf2 activation promotes lung cancer metastasis by inhibiting the degradation of Bach1

Education Department of Jiangxi Province (GJJ13198 and GJJ170021)

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doi: 10.1016/0014-5793(95)01524-8