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More recently, it is becoming well-recognized that a better understanding of cellular signaling pathways alternation under toxicological insult will benefit the risk assessment and early stage prediction of drug toxicity (Jennings et al., 2013)

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Few studies have observed performance benefits as a result of supplementing with specific dietary antioxidants [37] and many well controlled studies in this area have found no performance benefit [2123, 3942]

iPSCs produce most ATP through glycolysis while SC-cardiomyocytes produce most ATP using glucose, fatty acids, and lactate in OXPHOS (115) and NPCs rely predominantly on glycolysis rather than OXPHOS (116)

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For the temperature stresses, compared with the optimum growth temperature 29, at 25, 35 and 37, the growth of CK and recombinant yeast was approximately the same, while at 40, yeast in all the groups unable grow normally, which were inhibited by high temperature