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Antacids and diabetes medications can exacerbate the problem

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doi: 10.3390/ph16071052

Elevated NNMT is linked to: Reduced NAD+ availability Slower mitochondrial function Increased fat storage efficiency Higher risk for insulin resistance By reducing NNMT activity, 5-Amino-1MQ allows the body to maintain higher NAD+ levels, which can support better mitochondrial performance, improved fat oxidation, and more balanced energy metabolism

Here at iThrive, this is mostly one of the very first deficiencies we look for because correcting it completely changes how someone feels