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Glossary PCOS polycystic ovary syndrome HA hyperandrogenism IR insulin resistance OTUs operational taxonomic units HOMA-IR homeostasis model assessment of insulin resistance BMI body mass index PD phylogenetic diversity ACE abundance-based coverage estimator ASVs amplicon sequence variants PCoA principal coordinate analysis PERMANOVA permutational multivariate analysis of variance SVs sequence variants PLS-DA partial least squares discriminant analysis ANOVA analysis of variance NMDS non-metric multidimensional scaling ANOSIM analysis of similarities CCA canonical correspondence analysis RDA redundancy analysis CAP canonical analysis of principal coordinates PCA principal component analysis DHT dihydrotestosterone DHEA dehydroepiandrosterone BAs bile acids BCAAs branched chain amino acids SCFAs short chain fatty acids BSH bile salt hydrolase FMT fecal microbiota transplantation T testosterone DHEAS dehydroepiandrosterone sulfate PYY peptide YY GLP-1 glucagon-like peptide-1 FFAR2 free fatty acid receptor 2 FFAR3 free fatty acid receptor 3 ATP adenosine triphosphate GnRH gonadotropin-releasing hormone LH luteinizing hormone LPS lipopolysaccharide m6A N6-methyladenosine IL-6 interleukin-6 TNF- tumor necrosis factor- NLRP3 NOD-like receptor family pyrin domain containing 3 GCs granulosa cells FSH follicle-stimulating hormone CYP7A1 cholesterol 7-hydroxylase CDCA chenodeoxycholic acid TCDCA taurochenodeoxycholic acid LCA lithocholic acid DCA deoxycholic acid GDCA glycodeoxycholic acid FXR farnesoid X receptor TGR5 takeda G protein-coupled receptor 5 BAT brown adipose tissue cAMP cyclic adenosine monophosphate PKA protein kinase A DIO2 deiodinase 2 GATA3 GATA binding protein 3 IL-22 interleukin-22 ILC3s group 3 innate lymphoid cells IL-1 interleukin-1 GNB gram-negative bacteria TLR4 toll-like receptor 4 CD14 cluster of differentiation 14 JNK1 c-Jun N-terminal kinase 1 NF-B nuclear factor kappa-light-chain-enhancer of activated B cells IRS-1 insulin receptor substrate-1 IL-18 interleukin-18 17-HSD 17-hydroxysteroid dehydrogenase Esr2 estrogen receptor PCOM polycystic ovarian morphology TMAO trimethylamine N-oxide TMA trimethylamine FMOs flavin-containing monooxygenases NAFLD non-alcoholic fatty liver disease IL-17A interleukin-17A FAI free androgen index mTORC1 mammalian target of rapamycin complex 1 IRS-2 insulin receptor substrate-2 PKB protein kinase B BCKAs branched-chain -keto acids JNK c-Jun N-terminal kinase p38 p38 mitogen-activated protein kinase T2DM type 2 diabetes mellitus ROS reactive oxygen species 3-HSD 3-hydroxysteroid dehydrogenase CYP19A1 cytochrome P450 family 19 subfamily A member 1 SHBG sex hormone-binding globulin DHPAA 3,4-dihydroxyphenylacetic acid BMP bone morphogenetic protein AMH anti-mllerian hormone IPA indole-3-propionic acid AhR aryl hydrocarbon receptor ADC arginine decarboxylase DFMA difluoromethylarginine IBD inflammatory bowel disease CYP11A1 cytochrome P450 family 11 subfamily A member 1 CYP17A1 cytochrome P450 family 17 subfamily A member 1 ER endometrial receptivity GLUT-4 glucose transporter 4 PI3K phosphatidylinositol 3-kinase TCM traditional Chinese medicine BL bailin ZQLHR Zishen Qingre Lishi Huayu recipe

[2] Rabinovich D, Smadi Y

Integrating OS testing into clinical protocols ensures optimized therapeutic outcomes, personalized interventions, and minimizes potential adverse effects related to inappropriate AOX use

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doi: 10.1136/eb-2017-102753 25 VeronikiAAVasiliadisHSHigginsJPSalantiG