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Phase I safety trial: First-in-human study, typically 2050 healthy volunteers, establishing safe dose range, pharmacokinetics, and tolerability

Gene of the issue: ANO6 and Scott syndrome

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In the absence of erotic stimulation, 10 men with psychogenic (non-organic) erectile dysfunction received subcutaneous doses ranging from 0.025 to 0.157 mg/kg, while erections were monitored by RigiScan over a 6-hour period

Proteins were detected with the indicated antibodies listed in the Reagents and Tools table, and blots were imaged using Odyssey Imaging System