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Challenges in Stability, Delivery, and Toxicity Although AMPs hold great promise for the treatment of bacterial infections, the clinical use is encumbered by several major challenges, the most significant of which pertain to their susceptibility to host and bacterial proteolytic enzymes, thereby affecting their stability and diminishing their therapeutic half-life [177]

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The importance of dietary fibre in intestinal barrier health has been previously demonstrated, with mice fed on low-fibre diets found to be colonised with a greater abundance of Proteobacteria while also displaying increased intestinal permeability and an under developed mucosal layer (Schroeder et al