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The increase in melanin synthesis is considered the leading mechanism in lieu of inadequate melanin transfer [6]

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Leukemia 29:20392049 Richardson P, Perrot A, San-Miguel J, Beksac M, Spicka I, Leleu X et al (2021) Updates from ICARIA-MM, a phase 3 study of isatuximab (Isa) plus pomalidomide and low-dose dexamethasone (Pd) versus Pd in relapsed and refractory multiple myeloma (RRMM)

[190] The EMA clarified that the second dose should be administered three weeks after the first dose
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