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FDA Zepbound Medical Review (Soccio) escalation peak at weeks 16-20 +2.8/+5.1/+4.1 bpm, change over 20 bpm in about 10% of tirz vs 3.35% placebo, Japanese 15 mg abnormal-pulse 23.3% vs 7.1%

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Response came within a few hours with full documentation

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PMID 34493100

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It may also affect neurotransmitters such as dopamine and serotonin , raising interest in neurological applications

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Performing the injection Pinch a fold of skin at the injection site between your thumb and forefinger

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