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Pharm Res 27:832840 Tang RMY, Cheah IK, Yew TSK, Halliwell B (2018) Distribution and accumulation of dietary ergothioneine and its metabolites in mouse tissues

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Sandler, H., Kreth, J., Timmers, H

chronic liver disease and hepatitis may present with elevated levels Renal impairment : Reduced clearance can contribute to accumulation, though this is rarely clinically significant Solid tumours : Certain malignancies, particularly hepatocellular carcinoma and metastatic disease, may elevate B12 levels [3] Evidence suggests that unexplained markedly elevated B12 levels without supplementation may sometimes be associated with underlying disease

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Even when the funded-status goal is reached, an allocation to risk assets can be justified to the extent there is unhedgeable uncertainty surrounding the liability and/or some beneficiary value to surplus