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So, if your vitamin B12 is not working properly because your folate metabolism isnt working properly this causes homocysteine imbalances which are considered a serious health problem for anyone especially for those with MTHFR gene mutations. 4 Reactions to Methylfolate supplementation Individuals that cannot tolerate Methylfolate often have low B12 levels in their cells

10.3390/toxins10070296 76 SchmidtR.JagerV.de ZhlkeD.WolffC.BernhardtJ.CankarK.et al

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Under oxidative stress, excessive ROS emissions lead to mitochondrial damage, and loss or defects in mitochondrial energy production can enhance metabolic processes in the tricarboxylic acid (TCA) cycle, ETC, exacerbating ROS release and reducing antioxidant enzymes [81,82,83]

Consistently including vitamin B12-fortified foods to your diet a few times per day is yet another way to help increase and maintain adequate vitamin B12 levels