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Manuscript source: Invited manuscript Peer-review started: December 5, 2017 First decision: December 11, 2017 Article in press: February 7, 2018 Specialty type: Gastroenterology and hepatology Country of origin: France Peer-review report classification Grade A (Excellent): A Grade B (Very good): B Grade C (Good): C Grade D (Fair): 0 Grade E (Poor): 0 P- Reviewer: Chetty R, He ST, Savopoulos CG S- Editor: Wang JL L- Editor: A E- Editor: Li RF Contributor Information Vladimir Alexei Morozov, Center for HIV and Retrovirology, Department of Infectious Diseases, Robert Koch Institute, Berlin 13353, Germany

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Additional defects of lpd-3 mutants in fecundity, cold or freezing tolerance, locomotory behavior, and intestinal membrane integrity or permeability were also rescued by Lecithin (Fig