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Both are used in advanced peptide-based formulations

However, doses above 2.4 mg showed diminishing returns due to increased gastrointestinal side effects, including nausea, vomiting, and diarrhea

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& Govindaraju, T

377 Iron overload, following increased intake, which may in particular result from the use of iron-containing implants widely employed in orthopaedic surgery, 378 or can occur after haemorrhagic stroke, results in compensatory upregulation of glial iron transporters, and down-regulation of neuronal iron transporters, both aimed at neuroprotection