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This mechanism has been validated among lung cancer patients from four distinct geographic regions, suggesting that PM2.5 exposure may trigger lung cancer-related gene mutations through APOBEC3B and DDR (DNA damage response) pathway activation [151]

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The American Society of Health-System Pharmacists

There are two well-recognized clinical syndromes that result from immunologically mediated glomerular disease

So I know you touched a little bit about stress just now, but yeah, I mean that quote says a lot

The interpretation has been debated