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When mast cells are activated in response to progesterone, the resulting histamine surge helps explain many of the hallmark features of APD, including: Hives (urticaria) caused by histamine-induced blood vessel dilation Intense itching (pruritus) driven by histamine signaling in the skin Angioedema , or deeper swelling beneath the skin and mucous membranes Asthma-like symptoms or shortness of breath , due to histamines effects on airway smooth muscle This mast cellhistamine connection also clarifies why treatments that target allergic pathways are often effective in APD, even though progesterone is a hormone rather than a classic allergen

[DOI] [PMC free article] [PubMed] [Google Scholar] [130].Yang X, Chao X, Wang ZT, Ding WX

Current allergy and asthma reports, 13(1), 2732

Importantly, DSIP does not appear to generate the same type of dependency observed with opioid-based agents, despite some overlap in receptor pathways within the nervous system

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glutathione, and Vitamin C, it creates a synergistic effect that not only brightens the skin tone but also effectively addresses hyper-pigmentation while supporting the body's natural detoxification processes