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Several developer interviews even admit this

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Biomed (Taipei) (2015) 5(4):22

doi: 10.1016/j.idc.2021.03.011 13 ArendrupM

Furthermore, cellular experiments in a high-altitude rat model have shown that butyrate can downregulate the expression of HIF-1 by reducing the activity of lactate dehydrogenase A, which in turn attenuates the glycolytic pathway and alleviates cellular responses to hypoxic stress (Zhao et al., 2024)

To this end, 32D cells, a mouse myeloid progenitor line which proliferation is dependent on interleukin-3 (IL-3) 26 , were employed for WT- and T315I-Bcr-Abl transformation