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Burgos JI, Yeves AM, Barrena JP, Portiansky EL, Vila-Petroff MG, Ennis IL

NO is synthesized by eNOS in endothelial cells and diffuses to vascular smooth muscle, where it activates the cytosolic form of guanylate cyclase (also known as guanylyl cyclase) to form cyclic guanosine monophosphate (cGMP)

Additionally, it altered the microbial composition, increasing beneficial bacteria while reducing harmful ones, indicating broad protective effects on gut health during stress and infection [70]

[DOI] [PubMed] [Google Scholar] Patel R
