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CTCs show significantly increased tumorigenicity and metastatic potential in a novel orthotopic syngeneic model of metastatic cancer [52]

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Transcription factors (TFs) are a large class of sequence-specific DNA-binding proteins and act as key regulators of gene transcription

Moreover, excess iron could promote the formation of reactive oxygen species (ROS), which can lead to oxidative stress and DNA damage, with cytokine-regulated inflammatory pathways and a central contribution from innate immune cells in the tumor microenvironment (360, 361)

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