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In conclusion, the evolving landscape of glutamine deprivation strategies in cancer therapy highlights the diverse approaches to disrupting glutamine metabolism in specific vital cellular nodes

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doi: 10.3389/fncom.2017.00048 48 SizemoreAEGiustiCKahnAVettelJMBetzelRFBassettDS

A likely mechanism is that matrix swelling causes rupture of the outer membrane and release of the intermembrane proteins63

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