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However, no study to date has thoroughly examined how viral proteins simultaneously affect multiple cellular pathways, each controlled by its own feedback mechanisms, and how the disruption of these systems may interact to worsen or prolong disease

In serum and plasma, reduced GSH is primarily released by hepatocytes for uptake by the kidney, lung, intestine, and other organs [14]

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Glutamine requirements increase markedly, and its utilization may exceed endogenous production [51, 70]