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Front Microbiol 9:67

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A study in 2022 used this model to screen out a novel ALK5 inhibitor, TP-008, which reduced collagen deposition in mouse pulmonary fibrosis models by 70% (Luttens et al., 2025)

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Low to intermediate levels of ROS have been shown to activate both, receptor tyrosine kinase and Ca/calmodulin, the latter by the oxidation of Methionine 281 and 282 residues

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