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The chronic activation of the type I IFN pathway is a hallmark of SLE and contributes to the dysregulation of immune responses in this disease [132]

Experimental studies have utilized diverse animal models including transgenic mice (APP/PS1, 5FAD), senescence-accelerated mice (SAMP8), and even Drosophila melanogaster to explore these mechanisms

Stern JH, Tian Y, Funderburgh J, et al (2018) Regenerating Eye Tissues to Preserve and Restore Vision

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Renal interstitial infiltration and tertiary lymphoid organ neogenesis in IgA nephropathy