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When synaptic glutamate accumulates excessively, it leads to pathological overstimulation of ionotropic glutamate receptors, most notably the N-methyl-D-aspartate and -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors

doi: 10.1023/a:1012827221844 64 ChenZ-SGuoYBelinskyMGKotovaEKruhGD

Ortega-Alarcon D, Claveria-Gimeno R, Vega S, Jorge-Torres OC, Esteller M, Abian O, et al

BRAF plays a vital role in the mitogen-activated protein kinases/extracellular signal-regulated kinases (MAPK/ERK) signaling pathway, which influences cell growth and proliferation (226)

The transcriptional activity of the VDR is regulated not only by binding calcitriol but via the formation of heterodimers with the other nuclear receptors, specifically members of the RXR family

[DOI] [PubMed] [Google Scholar] [142].Chen B, Shen Z, Wu D, Xie X, Xu X, Lv L, Dai H, Chen J, Gan X, Glutathione peroxidase 1 promotes NSCLC resistance to cisplatin via ROS-induced activation of PI3K/AKT pathway