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Description
While SIRT1 overexpression reverses the inflammatory pathology, its underexpression promotes inflammation, as shown in experimental animals exposed to cigarette smoke or chronic obstructive pulmonary disease [341,342]

Early research is mostly from animal models, so the clinical picture is still forming

In addition to this, PEGylation (attachment of polyethylene glycol chains) has been employed for longer circulation time and reduced immunogenicity

doi: 10.3390/antiox13111396

The disease progression and symptoms of PD are unique from one patient to another, and their medications are decided based on the disease progression and symptoms of each patient
PMID 8544970
