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-Glucuronidase and -galactosidase cleavable linkers are the most used type of glycosidase-cleavable chemistry currently in use

While these direct endocrine effects form the core biological axis, their metabolic expression is further modulated by higher-order regulatory systems that integrate stress signaling, immune tone, microbial ecology, and behavioral adaptation

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Long-term safety with chronic use hasn't been established in rigorous clinical trials

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Plant Physiol Biochem 202:107981