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7 In fact, xCT is considered to be the main transporter of cystine in cancer (Table 1) 25,26,27 and its expression is controlled by nuclear factor erythroid 2-related factor 2 (NRF2), a master regulator of the cellular redox state, 28 highlighting the importance of xCT in an oxidative stress-resistant cancer cell phenotype

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By the physicians of Amanecia Health | Updated April 27, 2026 Last reviewed June 18, 2026 by Ann Czarnik, M.D., FACEP

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But if youre still tired, foggy, or feeling stuck, the issue may not be what youre doing